Title of article
Synthesis and antimycobacterial activity of new S-alkylisothiosemicarbazone derivatives Original Research Article
Author/Authors
Maria Teresa Cocco، نويسنده , , Cenzo Congiu، نويسنده , , Valentina Onnis، نويسنده , , Maria Luisa Pellerano، نويسنده , , Alessandro De Logu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
6
From page
501
To page
506
Abstract
A new series of S-alkylisothiosemicarbazones of 3- and 4-pyridincarboxaldehyde and 4-fluoro- and 4-trifluoromethylbenzaldehyde was synthesized and evaluated for biological activity against various Mycobacterium strains. Inhibitory activity against Mycobacterium tuberculosis H37Rv ATCC 27294 and INH-R ATCC 35822 was compared with activity against clinical isolated Mycobacteria as well as against MOTT. Some of newly prepared compounds showed best inhibitory values against clinical isolated Mycobacteria, besides to low citotoxicity values.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301987
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