Synthesis and biological evaluation of novel 2′-deoxy-4′-thio-imidazole nucleosides Original Research Article

A study on the use of 3′-directing groups for the synthesis of imidazole 2′-deoxy-4′-thionucleosides led to varying α:β ratios in the glycosylation reaction. The para-nitrobenzoyl group gave the optimum result in the glycosylation step; therefore, this protected thiosugar 10b was used for the synthesis of a series of novel 2′-deoxy-4′-thio-imidazole nucleosides which have been evaluated for antiviral activity in vitro.