Synthesis of Novel Polyphenols Consisted of Ferulic and Gallic Acids, and Their Inhibitory Effects on Phorbol Ester-Induced Epstein–Barr Virus Activation and Superoxide Generation Original Research Article

We prepared novel polyphenols which were esters composed of two naturally occurring products, ferulic and gallic acids, and investigated their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein–Barr virus (EBV) activation and superoxide (O2−) generation. Most of these compounds exhibited significant EBV activation suppression at a concentration of 20 μM and in particular, the ester 5f having 2-metyl-1-butyl group showed high activity. The suppressive effects on O2− generation were also observed in most of the esters.