Author/Authors :
Kousuke Tani، نويسنده , , Atsushi Naganawa، نويسنده , , Akiharu Ishida، نويسنده , , Kenji Sagawa، نويسنده , , Hiroyuki Harada، نويسنده , , Mikio Ogawa، نويسنده , , Takayuki Maruyama، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Kigen Kondo، نويسنده , , Masaaki Toda، نويسنده ,
Abstract :
Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of α- and ω-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an ω-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure–activity relationships are discussed.
