Phenylpiperazinylmethylindolecarboxylates and derivatives as selective D4-Ligands Original Research Article

Novel phenylpiperazinylmethylindolecarboxylates were synthesized for evaluation as potential D4-ligands. Test compounds showed high affinity for the human dopamine D4 receptor and great selectivity over the other receptor subtypes. Intrinsic effects of indole derivatives, which indicated most promising binding properties, were investigated in a mitogenesis assay.