Author/Authors :
Alexander Straub، نويسنده , , Jordi Benet-Buckholz، نويسنده , , Rita Fr?de، نويسنده , , Armin Kern، نويسنده , , Christian Kohlsdorfer، نويسنده , , Peter Schmitt، نويسنده , , Thomas Schwarz، نويسنده , , Hans-Martin Siefert، نويسنده , , Johannes-Peter Stasch، نويسنده ,
Abstract :
The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543 were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. These metabolites activate the soluble guanylate cyclase, induce vasoelaxation and thereby may contribute to the in vivo activity of BAY 41-2272 and BAY 41-8543.
