Efficient and highly stereoselective synthesis of a β-Lactam inhibitor of the serine protease prostate-specific antigen Original Research Article

An efficient synthesis of a β-lactam precursor of the serine protease, prostate-specific antigen inhibitor 1 has been accomplished. The synthesis relies on two completely stereoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner.