Author/Authors :
Alcides J.M. da Silva، نويسنده , , Camilla D. Buarque، نويسنده , , Fl?via V Brito، نويسنده , , Laure Aurelian، نويسنده , , Luciana F Macedo، نويسنده , , Linda H. Malkas، نويسنده , , Robert J Hickey، نويسنده , , Daniele V.S Lopes، نويسنده , , François Noël، نويسنده , , Yugo L.B Murakami، نويسنده , , Noelson M.V Silva، نويسنده , , Paulo A Melo، نويسنده , , Rodrigo R.B. Caruso، نويسنده , , Newton G. Castro، نويسنده , , Paulo R.R. Costa، نويسنده ,
Abstract :
Seven new 1,4-naphthoquinones structurally related to lapachol were synthesized from lawsone and oxygenated arylmercurials. These compounds can also be seen as pterocarpan derivatives where the A-ring was substituted by the 1,4-naphthoquinone nucleus. Pharmacological screening provided evidence of significant biological activities, including effects against proliferation of the MCF-7 human breast cancer cell line, against Herpes Simplex Virus type 2 infection, and against snake poison-induced myotoxicity. One derivative displaced flunitrazepam binding and showed benzodiazepine-like activity, suggesting novel neuroactive structural motifs.
