Title of article
QSAR studies on biological activity of piritrexim analogues against pc DHFR Original Research Article
Author/Authors
Vijay K. Agrawal، نويسنده , , Rashmi Sohgaura، نويسنده , , Keshav C. Mathur and Padmakar V. Khadikar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
8
From page
2919
To page
2926
Abstract
Quantitative structure–activity relationship (QSAR) studies for 2,6-substituted 2,4-diaminopyrido[3,2-d] pyrimidine analogues of piritrexim (PTX) as inhibitors of dihydrofolate reductase (DHFR) are now made using topological indices. The results have shown that best models are obtained by multiparametric analysis. The predictive potential of the model is discussed on the basis of a cross-validation method.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302224
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