Title of article :
Synthesis and properties of some novel anti-calmodulin drugs Original Research Article
Author/Authors :
Ted T. Sakai، نويسنده , , N.Rama Krishna، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Abstract :
The preparation and properties of some novel inhibitors of calmodulin function are described. The compounds are cationic derivatives of phenyl-substituted thiazoles which inhibit the calmodulin stimulation of cyclic-AMP phosphodiesterase and are active against animal tumor cells in culture. These derivatives form the basis for the preparation of new, more potent inhibitors of calmodulin function which could take advantage of the reported elevated levels of calcium-bound calmodulin in tumor cells and show preferential anti-tumor activity.
Keywords :
antagonists , Antineoplastics , Antiproliferative agents , Proteins
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry