Semisynthesis and cytotoxicity of amino acetogenins and derivatives Original Research Article

Semisynthetic derivatives were prepared from two natural annonaceous acetogenins, rolliniastatin- and squamocin, and their cytotoxicity was evaluated. Amino derivatives show decreased bioactivity. Isorolliniastatin- was found to be much less toxic than rolliniastatin- after intraperitoneal administration to mice, although the in vitro cytotoxicity of both compounds was comparable