Author/Authors :
Weidong He، نويسنده , , Miroslav Cik، نويسنده , , Luc Van Puyvelde، نويسنده , , Jacky Van Dun، نويسنده , , Giovanni Appendino، نويسنده , , Anne Lesage، نويسنده , , Ilse Van der Lindin، نويسنده , , Josee E. Leysen، نويسنده , , Walter Wouters، نويسنده , , Simon G Mathenge، نويسنده , , Francis P Mudida، نويسنده , , Norbert De Kimpe، نويسنده ,
Abstract :
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.
