Title of article
Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii Original Research Article
Author/Authors
Weidong He، نويسنده , , Miroslav Cik، نويسنده , , Luc Van Puyvelde، نويسنده , , Jacky Van Dun، نويسنده , , Giovanni Appendino، نويسنده , , Anne Lesage، نويسنده , , Ilse Van der Lindin، نويسنده , , Josee E. Leysen، نويسنده , , Walter Wouters، نويسنده , , Simon G Mathenge، نويسنده , , Francis P Mudida، نويسنده , , Norbert De Kimpe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
11
From page
3245
To page
3255
Abstract
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302396
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