Author/Authors :
Kristin M. Brinner، نويسنده , , Jin Mi Kim، نويسنده , , Hiromu Habashita، نويسنده , , Ilya Y. Gluzman، نويسنده , , Daniel E Goldberg، نويسنده , , Jonathan A Ellman، نويسنده ,
Abstract :
Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70–350 nM against chloroquine-resistant strains of Plasmodium falciparum.
