• Title of article

    Anti-MRSA cephems. Part 3: Additional C-7 acid derivatives Original Research Article

  • Author/Authors

    Dane M. Springer، نويسنده , , Bing-Yu Luh، نويسنده , , Jason T Goodrich، نويسنده , , Joanne J. Bronson، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2003
  • Pages
    11
  • From page
    281
  • To page
    291
  • Abstract
    Twenty-seven novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel acid moieties at C-7 that were synthesized using nucleophilic aromatic substitution reactions and Stille couplings. The most interesting compound (6) displayed an MIC90 against MRSA of 3.7 μg/mL, and an average PD50 of 3.9 mg/kg.
  • Journal title
    Bioorganic and Medicinal Chemistry
  • Serial Year
    2003
  • Journal title
    Bioorganic and Medicinal Chemistry
  • Record number

    1302521

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1302521