Author/Authors :
Leonor Y Vargas M، نويسنده , , Mar??a V Castelli، نويسنده , , Vladimir V. Kouznetsov، نويسنده , , Juan-Diego Urbina، نويسنده , , Silvia N L?pez، نويسنده , , Maximiliano Sortino، نويسنده , , Ricardo D. Enriz، نويسنده , , Juan Luis Ribas-Salgueiro، نويسنده , , Susana Zacchino، نويسنده ,
Abstract :
The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-β-d-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.
