Title of article :
Synthesis and antimycotic activity of N-azolyl-2,4-dihydroxythiobenzamides Original Research Article
Author/Authors :
Joanna Matysiak، نويسنده , , Andrzej Niewiadomy، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
7
From page :
2285
To page :
2291
Abstract :
N-pyrazole and N-1,2,4-triazole derivatives of 2,4-dihydroxythiobenzamide prepared from sulfinyl-bis-(2,4-dihydroxythiobenzoyl) and commercially available azole amines were tested for their antimycotic activity. The chemical structure of compounds was confirmed by IR, 1H NMR, MS and elemental analysis. The MIC values against the reference strain Candida albicans ATCC 10231, azole-resistant clinical isolates of Candida albicans and non-Candida albicans species were determined for their potential activity in vitro. The compounds exhibited comparable or higher activity than itraconazole and fluconazole tested under the same experimental conditions. Pyrazoline derivatives showed higher activity than other analogues. The strongest fungistatic activity for N-(2,3-dimethyl-1-phenyl-1,2-dihydro-5-oxo-5H-pyrazol-4-yl)-2,4-dihydroxythiobenzamide was found with MIC values significantly lower than those for the studied drugs.
Journal title :
Bioorganic and Medicinal Chemistry
Serial Year :
2003
Journal title :
Bioorganic and Medicinal Chemistry
Record number :
1302713
Link To Document :
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