Title of article
Synthesis and antiparasitic activity of albendazole and mebendazole analogues Original Research Article
Author/Authors
Gabriel Navarrete-V?zquez، نويسنده , , Lilian Yépez-Mulia، نويسنده , , Alicia Hern?ndez-Campos، نويسنده , , Amparo Tapia، نويسنده , , Francisco Hern?ndez-Luis، نويسنده , , Roberto Cedillo-Rivera، نويسنده , , José Gonz?lez، نويسنده , , Antonio Mart??nez-Fern?ndez، نويسنده , , Mercedes Mart??nez-Grueiro، نويسنده , , Rafael Castillo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
8
From page
4615
To page
4622
Abstract
Albendazole (Abz) and Mebendazole (Mbz) analogues have been synthesized and in vitro tested against the protozoa Giardia lamblia, Trichomonas vaginalis and the helminths Trichinella spiralis and Caenorhabditis elegans. Results indicate that compounds 4a, 4b (Abz analogues), 12b and 20 (Mbz analogues) are as active as antiprotozoal agents as Metronidazole against G. lamblia. Compound 9 was 58 times more active than Abz against T. vaginalis. Compounds 8 and 4a also shown high activity against this protozoan. Compounds 4b and 5a were as active as Abz. None of the Mbz analogues showed activity against T. vaginalis. The anthelmintic activity presented by these compounds was poor.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2003
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302781
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