Author/Authors :
Uma Ramachandran، نويسنده , , Alka Mital، نويسنده , , Prasad V Bharatam، نويسنده , , Smriti Khanna، نويسنده , , Poduri Rama Rao، نويسنده , , Krishnamoorthy Srinivasan، نويسنده , , Rakesh Kumar، نويسنده , , Harmander Pal Singh Chawla، نويسنده , , Chaman Lal Kaul، نويسنده , , Suryaprakash Raichur، نويسنده , , Ranjan Chakrabarti، نويسنده ,
Abstract :
Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARγ agonists evaluated.
Keywords :
PPARg agonists , Type 2 diabetes , Transactivitaion , Conformational rigidity , AM1 calculations , Pyridine analogues of TZDs
