Title of article
A new linker for glucuronylated anticancer prodrugs Original Research Article
Author/Authors
Freddy Rivault، نويسنده , , Isabelle Tranoy-Opalinski، نويسنده , , Jean-Pierre Gesson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
675
To page
682
Abstract
The synthesis, enzymatic hydrolysis and self decomposition of model glucuronylated prodrugs, incorporating a new linker with different aryl substituents, have been studied. Determination of kinetic parameters (Vmax, Km and t1/2) showed the important role of aromatic substitution in enzymatic recognition and linker decomposition.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302901
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