Title of article
Baylis–Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents Original Research Article
Author/Authors
S. Batra، نويسنده , , A.K. Roy، نويسنده , , A. Patra، نويسنده , , A.P Bhaduri، نويسنده , , W.R. Surin، نويسنده , , S.A.V. Raghavan، نويسنده , , P. Sharma، نويسنده , , K. Kapoor، نويسنده , , M. Dikshit، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
19
From page
2059
To page
2077
Abstract
The solution-phase parallel synthesis involving reactions of Baylis–Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.
Keywords
Platelet aggregation , Baylis–Hillman reaction , Isoxazolecarbaldehyde , isoxazole , Nucleophilic substitution , Substituted piperazine , Antithrombotic activity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303020
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