QSAR study on phenolic activity: need of positive hydrophobic term (logP) in QSAR Original Research Article

The phenolic activity (log1/C) of a large series of phenols against L1210 leukaemia cells was modelled using physicochemical parameters other than conventional electronic and steric parameters. Attempts have also been made to examine need or otherwise of the hydrophobic parameter, logP, in such studies. The results have shown that contribution of logP in modelling log1/C is favourable.