Title of article :
N-Aroyloxylthioxo-naphthalimides as DNA photocleavers of aroyloxyl oxygen radicals: synthesis, evaluation, and substituents’ effect Original Research Article
Author/Authors :
Yufang Xu، نويسنده , , Xiayu Huang، نويسنده , , Xuhong Qian، نويسنده , , Wei Yao، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Novel N-Aroyloxylthioxo-naphthalimides as highly efficient ‘time-resolved’ DNA photocleavers of aroyloxyl radicals type were designed and synthesized. The substituents at the aroyloxyl moiety have an important and unusual influence on the DNA photocleavage, and DNA photodamages of the compounds were unusually not depended on the electronic effects of substituents on the corresponding oxygen-centered radicals. With AM1 semi-empirical quantum calculation, it was found that their photocleaving activities were correlated with the densities of electron clouds on the N–O bonds in the triplet state. N-(m-Dichloro-benzoyloxy)-thioxo-naphthalimide could photodamage DNA effectively at less than the concentration of 2 μM.
Keywords :
Substituent effect , DNA photocleaver , Oxygen centered radical , Aroyloxylthioxonaphthalimides
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry