Title of article :
Cinnamic amides of (S)-2-(aminomethyl)pyrrolidines are potent H3 antagonists Original Research Article
Author/Authors :
Bernd Peschke، نويسنده , , Sonja Bak، نويسنده , , Rolf Hohlweg، نويسنده , , Ingrid Pettersson ، نويسنده , , Hanne Hoffmann Fr?lund Refsgaard، نويسنده , , Dorthe Viuff، نويسنده , , Karin Rimvall، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
New imidazole-free H3 antagonists have been found in a series of cinnamic amides of (S)-(aminomethyl)pyrrolidines. The influence of the substituent on the aromatic moiety on the potency and the inhibition of three cytochrome P450 subtypes are also described.
Keywords :
Diamine , Cinnamic amides , Cytochrome P450 , H3 antagonist
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
