QSPR of 3-aryloxazolidin-2-one antibacterials Original Research Article

A QSPR treatment has been applied to a data set consisting of 60 3-aryloxazolidin-2-one antibacterials to relate the in vitro minimum inhibitory concentration (MIC) (required to inhibiting growth of S. aureus) with theoretical molecular and fragment descriptors. The treatment using codessa pro descriptors leads to a seven-parameter model with r2=0.820 and r2cv=0.758.