Title of article
Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors Original Research Article
Author/Authors
Sheng Biao Wan، نويسنده , , Di Chen، نويسنده , , Q. Ping Dou، نويسنده , , Tak Hang Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
7
From page
3521
To page
3527
Abstract
The green tea polyphenol catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) were synthesized enantioselectively via a Sharpless hydroxylation reaction followed by a diastereoselective cyclization. Their potencies to inhibit the proteasome activity were measured. The unnatural enantiomers were found to be equally potent to the natural compounds.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303152
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