Title of article :
4′-α-C-Branched N,O-nucleosides: synthesis and biological properties Original Research Article
Author/Authors :
Ugo Chiacchio، نويسنده , , Filippo Genovese، نويسنده , , Daniela Iannazzo، نويسنده , , Anna Piperno، نويسنده , , Paolo Quadrelli، نويسنده , , Corsaro Antonino، نويسنده , , Roberto Romeo، نويسنده , , Vincenza Valveri، نويسنده , , Antonio Mastino، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
The synthesis of 4′-α–C-branched N,O-nucleosides has been described, based on the 1,3-dipolar cycloaddition of nitrones with vinyl acetate followed by coupling with silylated nucleobases, The obtained compounds have been evaluated for their activity against HSV-1, HSV-2, HTLV-1. Cytotoxicity and apoptotic activity have been also investigated: compound 10c shows moderate apoptotic activity in Molt-3 cells.
Keywords :
modified nucleosides , 1 , 3-dipolar cycloaddition , Antiviral activity , Apoptotic activity , C-Branched nucleosides
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
