Title of article
Synthesis of 1-(ω-aminoalkyl)naphthoindolediones with antiproliferative properties Original Research Article
Author/Authors
Andrey E. Shchekotikhin، نويسنده , , Vladimir N. Buyanov، نويسنده , , Maria N Preobrazhenskaya، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
3923
To page
3930
Abstract
The preparation and cytotoxic properties of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione derivatives carrying N-aminoalkyl substituents are described. The N-aminobutylnaphthoindolediones obtained were studied in National Cancer Institute Screening Program and demonstrated high antiproliferative activity against 60 human cancer cell lines. All N-(4-aminobutyl) derivatives have higher potency than adriamycin or mitoxantrone against adriamycin selected multidrug resistant breast cancer cell line NCI/ADR.
Keywords
Naphthoindolediones , O-Demethylation , N-Alkylation , Cytotoxicity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303173
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