Author/Authors :
Maria Koufaki، نويسنده , , Anastasia Detsi، نويسنده , , Elissavet Theodorou، نويسنده , , Christina Kiziridi، نويسنده , , Theodora Calogeropoulou، نويسنده , , Athanasios Vassilopoulos، نويسنده , , Angeliki P. Kourounakis، نويسنده , , Eleni Rekka، نويسنده , , Panos N. Kourounakis، نويسنده , , Catherine Gaitanaki، نويسنده , , Panagiota Papazafiri، نويسنده ,
Abstract :
Novel hybrids of lipoic acid and trolox connected through triamine spacers as well as analogues in which the lipoic acid was attached at different positions of the chroman moiety of vitamin E through an amide bond, were synthesized and exhibited strong inhibition of the microsomal lipid peroxidation. Moreover, the new molecules, at 1 μM concentration, reduced reperfusion arrhythmias and MDA content on isolated rat heart preparations, with the 2- and 5-subtituted chromans possessing the better cardioprotective activity.
Keywords :
Chroman , Lipoic acid , Lipid peroxidation , Reperfusion arrhythmias
