Title of article
Synthesis of polyhydroxylated piperidines and evaluation as glycosidase inhibitors Original Research Article
Author/Authors
Tony Tite، نويسنده , , Marie-Christine Lallemand، نويسنده , , Erwan Poupon، نويسنده , , Nicole Kunesch، نويسنده , , Francois Tillequin، نويسنده , , Christine Gravier-Pelletier، نويسنده , , Yves Le Merrer، نويسنده , , Henri-Philippe Husson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
7
From page
5091
To page
5097
Abstract
A series of 16 new chiral nonracemic polyhydroxylated piperidines was synthesized utilizing several chiral β-amino-alcohols. They act as a nitrogen source, chirality inducer and iminium stabilizer, in the desymmetrization of meso-trihydroxylated glutaraldehyde. The biological activity of these compounds towards several glycosidases (α-d-glucosidase, α-d-mannosidase, α-l-fucosidase) has been evaluated.
Keywords
Biological activities , Glycosidases , Chiral nonracemic polyhydroxylated piperidines
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303276
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