Author/Authors :
Alicia Torrado، نويسنده , , Carlos Lamas، نويسنده , , Javier Agejas، نويسنده , , Alma Jimenez، نويسنده , , Nuria D??az، نويسنده , , Jeremy Gilmore، نويسنده , , John Boot، نويسنده , , Jeremy Findlay، نويسنده , , Lorna Hayhurst، نويسنده , , Louise Wallace، نويسنده , , Richard Broadmore، نويسنده , , Rosemarie Tomlinson، نويسنده ,
Abstract :
A series of compounds combining the naphthylpiperazine and thienopyran scaffolds has been prepared and evaluated for 5-HT reuptake inhibition with 5-HT1D antagonist activity. The design of these compounds has been based on the ‘overlapping type’ strategy where two pharmacophores are linked in a single molecule. The resultant dual pharmacological profile has the potential to deliver a more efficient treatment for depression.
