Synthesis of new 6-alkylvinyl/arylalkylvinyl substituted 1,2,4-trioxanes active against multidrug-resistant malaria in mice Original Research Article

3-Alkyl/arylalkyl substituted 2-butenols 9, 10, 23a–d undergo regiospecific photooxygenation to furnish β-hydroxyhydroperoxides 11, 12, 24a–d, respectively, in reasonable yields. Acid catalyzed condensation of 11, 12, 24a–d with various ketones furnish new 1,2,4-trioxanes 13–18, 25a–d, 26a–d, 27a–d in good yields. Several of these trioxanes show promising antimalarial activity against multidrug-resistant Plasmodium yoelii in mice by oral and intramuscular routes.