Synthesis and antimalarial activity of 6-cycloalkylvinyl substituted 1,2,4-trioxanes Original Research Article

6-Cycloalkylvinyl substituted 1,2,4-trioxanes 6–15 have been prepared and tested against multi-drug resistant Plasmodium yoelii in mice. The most active trioxane 11 provides 80% protection to the treated mice. Further derivatization of 11 leads to decrease in antimalarial activity.