Title of article
Synthesis and antimalarial activity of 6-cycloalkylvinyl substituted 1,2,4-trioxanes Original Research Article
Author/Authors
Chandan Singh، نويسنده , , Naveen Chandra Srivastav، نويسنده , , Sunil K. Puri، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
5745
To page
5752
Abstract
6-Cycloalkylvinyl substituted 1,2,4-trioxanes 6–15 have been prepared and tested against multi-drug resistant Plasmodium yoelii in mice. The most active trioxane 11 provides 80% protection to the treated mice. Further derivatization of 11 leads to decrease in antimalarial activity.
Keywords
Artemisinin , Antimalarial 1 , 4-trioxane , 2 , Photooxygenation , Plasmodium yoelii
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303333
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