Author/Authors :
Ying Chen، نويسنده , , Qian Zhang، نويسنده , , Beina Zhang، نويسنده , , Peng-Xia Liu، نويسنده , , Yi Xia، نويسنده , , Zheng-Yu Yang، نويسنده , , Nicole Kilgore، نويسنده , , Carl Wild، نويسنده , , Susan L. Morris-Natschke، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Abstract :
Two thia-DCK analogs (3a,b) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Compound 3a showed potent anti-HIV activity with an EC50 value of 0.14 μM and a therapeutic index of 1110. However, the corresponding 6-tert-butyl-substituted compound (3b) showed no suppression. The bioassay results indicated that thia-DCK analogs merit attention as potential HIV-1 inhibitors.
