Title of article
Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation Original Research Article
Author/Authors
Thota Ganesh، نويسنده , , Andrew Norris، نويسنده , , Shubhada Sharma، نويسنده , , Susan Bane، نويسنده , , Ana A. Alcaraz، نويسنده , , James P. Snyder، نويسنده , , David G.I Kingston، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
3447
To page
3454
Abstract
A strategy for the design and synthesis of simplified paclitaxel analogs based on the T-Taxol conformation is presented. The resulting compounds have both cytotoxic and tubulin polymerization activities, although less so than those of paclitaxel itself.
Keywords
Taxol , Paclitaxel , Cytotoxicity , tubulin , Molecular modeling , Synthesis , Olefin metathesis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303402
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