Author/Authors :
Alejandra Gerpe، نويسنده , , Gabriela Aguirre، نويسنده , , Luc?a Boiani، نويسنده , , Hugo Cerecetto، نويسنده , , Mercedes Gonzalez-Wangüemert، نويسنده , , Claudio Olea-Azar، نويسنده , , Carolina Rigol، نويسنده , , Juan D. Maya، نويسنده , , Antonio Morello، نويسنده , , Oscar E. Piro، نويسنده , , Vicente J. Ar?n، نويسنده , , Amaia Azqueta، نويسنده , , Adela L?pez de Cer?in، نويسنده , , Antonio Monge، نويسنده , , Mar?a Antonieta Rojas، نويسنده , , Gloria Yaluff، نويسنده ,
Abstract :
A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N1-oxide exhibited interesting antichagasic activity on the two parasitic strains and the two parasitic stages evaluated. Furthermore, besides its trypanocidal activity, 3-cyano-2-(4-nitrophenyl)-2H-indazole N1-oxide showed leishmanocidal activity in the three parasitic strains evaluated. To gain insight into the mechanism of action, electrochemical behaviour, ESR experiment, inhibition of parasitic respiration and QSAR were performed.
