Title of article
Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi Original Research Article
Author/Authors
Ana Cristina Lima Leite، نويسنده , , Renata Souza de Lima، نويسنده , , Diogo Rodrigo de M. Moreira، نويسنده , , Marcos Ver?ssimo de O. Cardoso، نويسنده , , Ana Carolina Gouveia de Brito، نويسنده , , Luciene Maria Farias dos Santos، نويسنده , , Marcelo Zaldini-Hernandes، نويسنده , , Alice Costa Kiperstok، نويسنده , , Ricardo Santana de Lima، نويسنده , , Milena B.P. Soares، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
9
From page
3749
To page
3757
Abstract
A novel series of thiosemicarbazone and aminoacyl-thiazolidones derivatives were synthesized. Their structure suggests that these compounds could have anti-Trypanosoma cruzi activity. Biological evaluation indicates that some of these compounds are able to inhibit the growth of T. cruzi in concentrations non-cytotoxic to mammalian cells. Docking studies were carried out in order to investigate the binding pattern of these compounds for the T. cruzi cruzain (TCC) protein, and these showed a significant correlation with experimental data.
Keywords
Thiosemicarbazones , Acyl-hydrazones , Aminoacyl-thiazolidones , Anti-Trypanosoma cruzi compounds , Docking studies
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303460
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