Title of article
Design of novel nicotinic ligands through 3D database searching Original Research Article
Author/Authors
Luca Guandalini، نويسنده , , Elisabetta Martini، نويسنده , , Silvia Dei، نويسنده , , Dina Manetti، نويسنده , , Serena Scapecchi، نويسنده , , Elisabetta Teodori، نويسنده , , M. Novella Romanelli، نويسنده , , Katia Varani، نويسنده , , Giovanni Greco، نويسنده , , Loredana Spadola، نويسنده , , Ettore Novellino، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
9
From page
799
To page
807
Abstract
A series of quinoline derivatives have been designed on the basis of results from a 3D search of the Cambridge Structural Database using the nicotinic pharmacophore as a query and further modified using molecular modeling. Some of the synthesized compounds show nanomolar affinity for the central nicotinic receptor on rat cerebral cortex.
Keywords
3D database search , nicotinic receptor , Molecular modeling
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303554
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