Title of article :
Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series Original Research Article
Author/Authors :
Franck Amblard، نويسنده , , Vincent Aucagne، نويسنده , , Pierre Guenot، نويسنده , , Raymond F. Schinazi، نويسنده , , Luigi A. Agrofoglio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The synthesis of novel acyclic nucleosides in the 5-alkynyl and 6-alkylfuro[2,3-d]pyrimidine series is described. These compounds were evaluated against HIV and HSV in order to determine their spectrum of antiviral activity. Their cytotoxicities against PBM, CEM and VERO cells were also determined. Compounds 21d and 24b displayed moderate EC50s of 2.7 and 4.9 μM, respectively, against HIV-1 and of 6.3 and 4.8 μM, respectively, against HSV. Nevertheless, these compounds also showed cellular toxicity, suggesting that the antiviral effects are secondary to the toxic effects.
Keywords :
Nucleosides , Furopyrimidine , Antiviral activity
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry