Title of article
Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates Original Research Article
Author/Authors
Ahmed Kamal، نويسنده , , V. Devaiah، نويسنده , , K. Laxma Reddy، نويسنده , , M. Shiva Kumar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
9
From page
2021
To page
2029
Abstract
Fluoroquinolones have been synthesized and linked to DC-81 at C8 position through different alkyl chain spacers. These PBD conjugates have exhibited good DNA binding affinity, and a representative compound shows promising in vitro anticancer activity.
Keywords
Cytotoxicity , Pyrrolobenzodiazepines , Fluoroquinolones , DNA binding ability
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303732
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