Title of article :
Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates Original Research Article
Author/Authors :
Ahmed Kamal، نويسنده , , V. Devaiah، نويسنده , , K. Laxma Reddy، نويسنده , , M. Shiva Kumar، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Fluoroquinolones have been synthesized and linked to DC-81 at C8 position through different alkyl chain spacers. These PBD conjugates have exhibited good DNA binding affinity, and a representative compound shows promising in vitro anticancer activity.
Keywords :
Cytotoxicity , Pyrrolobenzodiazepines , Fluoroquinolones , DNA binding ability
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
