Title of article :
New naphthylcombretastatins. Modifications on the ethylene bridge Original Research Article
Author/Authors :
Ana B. S?nchez Maya، نويسنده , , Concepci?n Pérez-Melero، نويسنده , , Nélida Salvador-Tormo، نويسنده , , Rafael Pelaez Lamamie de Clairac، نويسنده , , Esther Caballero، نويسنده , , Manuel Medarde، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues.
Keywords :
Naphthalene , Heterocycle bridged , Cytotoxicity , Tubulin polymerization inhibition , Combretastatin analogues
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
