Author/Authors :
Sheng Biao Wan، نويسنده , , Kristin R. Landis-Piwowar، نويسنده , , Deborah J. Kuhn، نويسنده , , Di Chen، نويسنده , , Q. Ping Dou، نويسنده , , Tak Hang Chan، نويسنده ,
Abstract :
The structure–activity relationship of a number of synthetic green tea polyphenol analogs involving modifications of A ring and B ring of epi-gallocatechin gallate (EGCG) as proteasome inhibitors has been examined. It was found that in B ring, a decrease in the number of OH groups led to decreased potency. Introduction of a hydrophobic benzyl group into the 8 position of A ring did not significantly affect the proteasome-inhibitory potency.
