Title of article
Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives Original Research Article
Author/Authors
Kyoko Nakagawa-Goto، نويسنده , , Jiu-Hong Wu، نويسنده , , Kenneth F. Bastow، نويسنده , , Chin-Chung Wu، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
2325
To page
2330
Abstract
New analogs of desmosdumotin C (1), in which other aromatic rings replaced the terminal phenyl group and the A-ring was modified, were synthesized. Compounds 2–9, 13, and 16 were evaluated in vitro against human tumor cell replication. The 4-bromophenyl analog (2) showed potent cytotoxic activity in four different tumor cell lines.
Keywords
Desmosdumotin C analogs , Cytotoxicity , Antitumor
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303756
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