Title of article
Direct diazo-transfer reaction on β-lactam: Synthesis and preliminary biological activities of 6-triazolylpenicillanic acids Original Research Article
Author/Authors
Po C. Chen، نويسنده , , Rebekah E. Wharton، نويسنده , , Pratiq A. Patel، نويسنده , , Adegboyega K. Oyelere، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
13
From page
7288
To page
7300
Abstract
In this study we report the first example of a direct diazo-transfer reaction on readily available 6-aminopenicillanates to give 6-azidopenicillanates in high yield. Subsequent Cu(I)-catalyzed Huisgen cycloaddition between these 6-azidopenicillanates and assorted terminal alkynes facilely furnished 6-triazolylpenicillanic acids. Preliminary biological screening indicates that these triazolylpenicillanic acids possess low to moderate antibacterial activities.
Keywords
Huisgen cycloaddition , Antibiotic , Penicillin , Click chemistry , 6-Triazolylpenicillanic acids , terminal alkynes , diazo-transfer , ?-lactam , Azide
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303816
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