Author/Authors :
Aline F. Taveira، نويسنده , , Mireille Le Hyaric، نويسنده , , Elaine F.C. Reis، نويسنده , , Débora P. Ara?jo، نويسنده , , Ana Paula Ferreira، نويسنده , , Maria Aparecida de Souza، نويسنده , , L?via L. Alves، نويسنده , , Maria C.S. Lourenço، نويسنده , , Felipe Rodrigues C. Vicente، نويسنده , , Mauro V. de Almeida، نويسنده ,
Abstract :
A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5 μg/mL. The presence of the carbohydrate slightly affected the antibacterial activity.
Keywords :
N-Alkylation , Mycobacterium tuberculosis , amino alcohol , d-Galactose
