Title of article
Novel imidazo[1,2-a]pyrazine derivatives as potent reversible inhibitors of the gastric H+/K+-ATPase Original Research Article
Author/Authors
Peter Jan Zimmermann، نويسنده , , Christof Brehm، نويسنده , , Wilm Buhr، نويسنده , , Andreas Marc Palmer، نويسنده , , Jürgen Volz، نويسنده , , Wolfgang-Alexander Simon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
536
To page
541
Abstract
A series of novel 6-substituted imidazo[1,2-a]pyrazines were synthesized via palladium catalyzed amino- or alkoxycarbonylation as key step. The anti-secretory activity of these compounds has been assessed in a binding assay against H+/K+-ATPase from hog gastric mucosa. Some of the compounds proved to be potent inhibitors of the gastric acid pump.
Keywords
Anti-ulcer , H+/K+-ATPase , 2-a]pyrazine , P-CAB , Carbonylation
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303926
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