Title of article :
New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania Original Research Article
Author/Authors :
Paulino Delgado-Méndez، نويسنده , , Nora Herrera، نويسنده , , Haydee Ch?vez، نويسنده , , Ana Estévez-Braun، نويسنده , , Angel G. Ravelo، نويسنده , , Fernando Cortés Pizano، نويسنده , , Santiago Castanys، نويسنده , , Francisco Gamarro، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Two new sesquiterpenes (1–2) and one new lupane triterpene (3) have been isolated from the roots of Maytenus apurimacensis. The novel β-dihydroagarofurans are the first sesquiterpenes with a basic polyhydroxy skeleton of 15-deoxyalatol and 4,15-dideoxyalatol that show high MDR reversing activity in the protozoan parasite Leishmania tropica.
Keywords :
Terpenoids , Dihydro-?-agarofuran sesquiterpenes , Celastraceae , Lupanes , Leishmania , Maytenus , MDR
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
