Title of article
Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents Original Research Article
Author/Authors
Na Xue، نويسنده , , Xiaochun Yang، نويسنده , , Rui Wu، نويسنده , , Jing Chen، نويسنده , , Qiaojun He، نويسنده , , Bo Yang، نويسنده , , Xiuyang Lu، نويسنده , , Yongzhou Hu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
2550
To page
2557
Abstract
A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo.
Keywords
Antitumor agents , Imidazol-2-one derivatives , Synthesis , Cytotoxicity , Combretastatin A-4
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304091
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