Title of article
Synthesis of curcumin mimics with multidrug resistance reversal activities Original Research Article
Author/Authors
Yumi Um، نويسنده , , Sungsik Cho، نويسنده , , Ho Bum Woo، نويسنده , , Yong Kee Kim، نويسنده , , Hanna Kim، نويسنده , , Jungyeob Ham، نويسنده , , Su-Nam Kim، نويسنده , , Chan Mug Ahn، نويسنده , , Seokjoon Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
3608
To page
3615
Abstract
In order to discover novel multidrug resistance (MDR) reversal agents for efficient cancer chemotherapy, the unsymmetrical curcumin mimics with various amide moieties (6–19) were synthesized and evaluated their MDR reversal activities in MDR cell line KBV20C. Among the tested compounds, 13, 16, and 17 showed potent MDR reversal activities by inhibiting drug efflux function of P-glycoprotein in KB20C cells, and almost recovered the cytotoxicity of vincristine and paclitaxel against KBV20C cell to the degree of potency against drug sensitive KB cells.
Keywords
Multidrug resistance reversal activities , Multidrug resistance , Anticancer , Curcumin , Curcumin mimics
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304192
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