Title of article :
Design and synthesis of trans 2-(furan-2-yl)vinyl heteroaromatic iodides with antitumour activity Original Research Article
Author/Authors :
Cosimo Gianluca Fortuna، نويسنده , , Vincenza Barresi، نويسنده , , Giuliano Berellini، نويسنده , , Giuseppe Musumarra، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A new molecular modelling approach based on physico-chemical and pharmacokinetic properties, called Volsurf plus, was used to design new heterocyclic compounds with antiproliferative activity. The synthesis and in vitro antitumour tests on a breast carcinoma cell line (MCF7) confirmed VOLSURF predicted activity values.
Keywords :
Gold , Asinex , Structure-based virtual screening , SARS-3CLpro inhibitor
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
