Title of article :
Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers Original Research Article
Author/Authors :
F. Scott Kimball، نويسنده , , Brandon J. Turunen، نويسنده , , Keith C. Ellis، نويسنده , , Richard H. Himes، نويسنده , , Gunda I. Georg، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
An enantiospecific synthesis was developed to generate both enantiomers of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one. A biological assay utilizing the HCT-116 colon cancer cell line to determine the cytotoxicity of these analogs revealed that only the (R)-enantiomer exhibited appreciable cytotoxicity with an IC50 value of 0.2 μM.
Keywords :
Tetrahydroindolizinones , Enantiospecific synthesis , HCT-116 , Colon cancer
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
